Publications

Abstract: Background: The hippocampus plays a pivotal role in memory formation and spatial navigation, its structure and function subject to modulation by various factors, including neuroplasticity. Despite its therapeutic efficacy in severe depression, the specific effects of Electroconvulsive Shock (ECS) therapy on hippocampal neuroplasticity remain poorly understood. Materials and Methods: This study, conducted at St. John’s Medical College, Bangalore, aimed to evaluate the impact of ECS on hippocampal neuroplasticity. Inbred male Wistar rats underwent ECS treatment for six consecutive days, followed by Golgi staining of hippocampal tissue. Morphometric analysis was conducted to assess dendritic node counts. Results: The study revealed significant differences in dendritic node counts between the ECS-treated and control groups (mean difference: 9.24 nodes, p ≤ 0.002), indicating ECS's potential to modulate hippocampal neuroplasticity. Conclusion: ECS therapy may serve as a modulator of hippocampal neuroplasticity, shedding light on its therapeutic mechanisms in neurological disorders. These findings contribute to our understanding of hippocampal function and dysfunction, informing future treatment strategies.