Publications
Effect of Turmacin supplementation on joint discomfort and functional outcome among healthy participants – a randomized placebo-controlled trial.
Jeffrey Pradeep Raj 1, Shreeraam Venkatachalam 2, Pranathi Racha 3, Sreejith Bhaskaran 4, Rajkumar S Amaravati Objective: To evaluate the effect of Turmacin, a standardized Curcuma longa extract rich in turmerosaccharides, on knee joint discomfort in healthy adults undergoing strenuous activity. Methods: In this double-blind, randomized, placebo-controlled trial, 90 healthy participants received Turmacin 0.5 g, Turmacin 1 g, or placebo once daily for 84 days and performed a 10-minute strenuous exercise task. Results: Both Turmacin groups showed significantly lower pain scores than placebo from day 5–7 onward and demonstrated delayed onset of pain on survival analysis. Turmacin 0.5 g significantly improved knee range of motion and quadriceps muscle force compared to placebo. Turmacin 1 g also showed better preservation of muscle function in within-group analyses.Conclusion: Turmacin (0.5 g and 1 g) effectively increased pain threshold and improved knee function in healthy adults, with only minor adverse events.