Projects

Project Description

Type 2 diabetes mellitus (T2DM) has reached epidemic proportions and is associated with various consequences. India is been reported as one of the epi center of this ongoing burden of the T2DM. Currently used therapies aim to delay progression of T2DM. Their efficacy could drastically be improved if implemented at earlier stages. Classical diagnostic markers are generally detected once metabolic imbalance has already set in. Therefore, development

of biomarkers for early diagnosis would help identify individuals at risk for developing

T2DM and its complication. MicroRNA-based prognosis, diagnosis, and disease

management are emerging as a novel idea in the context of T2DM. The expression level of

miRNAs not only offers an assessment of pathological state of disease, but also been proposed to be used as a therapeutics target in the near future. Utility of microRNA based

analysis as potential diagnostic and prognostic markers has never been studied among

Indians. Even when studied in the available literature targeted specific microRNA

particularly among prediabetes and diabetes with spectrum of complications are limited. The

implications of lifestyle modification on the reversibility of glycaemia in context to

microRNA is hardly been evaluated. In this study we propose to study the potential role of

circulating microRNA as a prognostic and early diagnostic markers among Indians with

T2DM. Current study will also follow the prediabetes population for 16 weeks to assess the

role of lifestyle modification on the circulating microRNA levels.