Publications

The purpose of the study was to evaluate the
safety and efficacy with the use of BMP-2 for treating
persistent non-unions in children with underlying complex
conditions. Between October 2006 and November 2010 in
our unit, 15 patients were treated with rhBMP-2 to enhance
bone union. There were nine females and six males with a
mean age of 9.5 years (range 4–15) at time of surgery.
Seventy-five per cent of the patients required revision of
internal fixation with insertion of rhBMP-2 to the nonunion
site, and the reminder had freshening of the nonunion
site with rhBMP-2 application. Patients had undergone
a mean of 2 (1–5) operations prior to implantation of
rhBMP-2. All the patients in the study group were available
for review with mean follow-up of 44 months (range
21–70). The mean time to union was 16 weeks (range
10–28 weeks). No adverse events related to BMP-2
application were noted in our study group. Healing
occurred clinically and radiographically in 16 of the 17
sites. Our study demonstrates that BMP-2 enhances healing
of the persistent non-unions without any adverse events
Keywords Bone  Congenital abnormalities non-union rhBMP-2