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Sudden Onset Abdominal Wall Swellings in Patient of Liver Cirrhosis

Groups and Associations Mallikarjun Patil drmalli_arjun@yahoo.co.in ∙ Keyur A. Sheth ∙ Kullembella S. Prasanna ∙ Channagiri K. Adarsh ∙ Balaraju Girisha
Journal of Clinical and Experimental Hepatology, 2012

Abstract

Spontaneous hematomas in cirrhotic patients are uncommon. Severe coagulopathy in advanced hepatic disease is characterized by both coagulation factor deficiencies and accelerated fibrinolysis. Hyperfibrinolysis in cirrhosis is a result of excess fibrin breakdown leading to defective hemostasis. We present a case of spontaneous hematomas with an acute drop in hemoglobin level, in a patient with cirrhosis which was due to primary hyperfibrinolysis.

Keywords

  1. cirrhosis
  2. muscle hematomas
  3. primary hyperfibrinolysis

Abbreviations

  1. aPTT (Activated partial thromboplastin time)
  2. FDPs (Fibrin degradation products)
  3. tPA (Tissue plasminogen activator)
  4. PAI-1 (Plasminogen activator inhibitor 1)
  5. TAFI (Thrombin-activatable fibrinolysis inhibitor)
  6. DIC (Disseminated intravascular coagulation)
  7. EACA (Epsilon amino-caproic acid)
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