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Home / Publications / Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process. Indian journal of critical care medicine: peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2019 Jan;23(1):15

Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process. Indian journal of critical care medicine: peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2019 Jan;23(1):15

Groups and Associations Amarja H, Bhuvana K, Sriram S
IJCCM 2019

Abstract

Context: Weaning induced cardiac dysfunction can occur without underlying heart disease. Changes in intrathoracic pressure, systemic vascular resistance, preload and afterload leading to heart-lung interactions are the possible explanatory mechanisms.

Aims: The aim of the current study was whether the assessment and identification of cardiac dysfunction induced during the weaning process could predict the outcome of extubation.

Settings and design: A prospective observational study with convenience sampling method was conducted from May 2015 to April 2016 after institutional ethical committee approval (ref 161/2015).

Materials and methods: Patients over eighteen and planned for extubation were included. Weaning method used was a spontaneous breathing trial (SBT) by pressure support-positive end-expiratory pressure (PS-PEEP). Baseline characteristics, weaning, and echocardiography parameters were collected pre extubation. Post-extubation echocardiographic parameters were collected within six hours as per the protocol. The primary outcome was extubation failure (reintubation within 48 hours). Secondary outcomes were ICU length of stay and ICU mortality.