Publications
Microarray analysis reveals distinct immune signatures in BCR-ABL positive and negative myeloproliferative neoplasms
Cecil Ross 1, Mugdha Sharma 1, John Paul 1, Sweta Srivastava 2 Abstract
Background: BCR-ABL mutation on the Philadelphia chromosome is the key driver of chronic myeloid leukemia (CML) pathogenesis. However, there are certain cases of myeloproliferative neoplasms (MPN) wherein no inherent driver mutation is detected resulting in clinical phenotype. It is important to identify key genes and pathways in driving the disease. The aim of the study was to use a gene-based omics approach to molecularly characterize these mutation-positive and negative cases to further strengthen diagnostics and precision medicine.