Publications
Impact of using Reference Change value of serum creatinine in the diagnosis, staging and outcome of Acute kidney injury in critically ill children: An interim analysis
Shiri S, Vasudevan A, Joseph S, Thomas T, AV L and Devanath A The initial diagnosis and staging of AKI by KDIGO creati-nine criteria is based on small increase of serum creatinine (sCr) from baseline. To estimate if a change in sCr represents a true change in child, the intrinsic or intra-individual biological variation (CVi) of sCr must be taken into account.Objective :To estimate the reference change value (CVi) of serum creatinine in Indian children. To compare the burden and severity of AKI in critically ill children according to “paediatric reference change value optimized for AKI in children” (pROCK) and KDIGO creat- inine criteria (0.3 mg/dL or 50% increase from baseline), and their association with morbidity and risk of in-hospital mortality.
