Publications
Genomic Insights into the emergence of Carbapenem-Resistant Salmonella Typhi harboring blaNDM-5 in India
T Tharani Priya, Jobin John Jacob, T Monisha Priya, Mahantesh, Bhavana, Suhani, Savitha Nagaraj, Jayanthi Savio, Priyadarshini A Padaki, J Sudarsana, Ashalatha Nair, Suganya Verma, Raman Gaikwad, Divya Joshi, Vasant C Nagvekar, Camilla Rodrigues, S Pavithra, B Santhosh K, Jacob John, Kamini Walia, Balaji Veeraraghavan Background The rising antimicrobial resistance in Salmonella Typhi presents a critical public health challenge by limiting effective treatment options. This highlights the importance of sustained genomic surveillance of the high-risk lineages and antimicrobial resistance determinants of S. Typhi to inform and support the implementation of typhoid vaccination programs, especially in endemic regions. In this context, we investigated a recent outbreak of carbapenem-resistant Salmonella Typhi in India, to elucidate the genomic epidemiology, resistance mechanisms, and evolution of drug resistance.
