Publications

Abstract 

Introduction

To compare the effects of Mirabegron versus Tamsulosin on improving symptoms and QoL in patients with indwelling ureteral stents using the validated version of USSQ questionnaire. Materials and methods This study was conducted on 200 patients (men and women) who underwent DJ stenting after uneventful endourological surgeries. Total of 150 patients reported DJ SRS, they were randomized into 3 groups (A, B, and C) in a ratio of 1: 1: 1. Group A were put on placebo, Group B on Tab Mirabegron 50mg OD, and Group C on Tab Tamsulosin 0.4mg OD. They were given the USSQ questionnaire and asked to complete it on the first week to see the magnitude of DJ SRS and third week before the DJ stent was removed. Results Study included total of 141 patients. All baseline characteristics (age, sex, side, indication, length, and duration of stent) were comparable. Average Urinary scores (USs) were 35.20, 35.8, 35.43 at 1st week and 21.64, 17.68, 36.7 at 3rd week, average pain scores (PSs) were 27.54, 28.34, 28 at 1st week and 14.86, 24.03, 26.7 at 3rd week and average sexual scores (SSs) were 7.34, 7.2, 7.2 at 1st week and 2.31, 2.17, 6.2 at 3rd week for Mirabegron, Tamsulosin, placebo respectively. Conclusion Tamsulosin improved USs. Mirabegron decreased the PSs and analgesic requirement. Mirabegron also improved WHSs, GHSs. Patients who are burdened by side effects or less improved on treatment with alphablockers or antimuscarinics could be additionally given or alternatively given Mirabegron to attenuate DJ SRS.